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BNP and NT-proBNP
Also known as: Brain natriuretic peptide, proBNP
Formal name: B-type natriuretic peptide, N-terminal pro b-type natriuretic peptide
Related tests: Cardiac biomarkers
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The Test Sample
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What is being tested?These tests measure the concentration of BNP or NT-proBNP in the blood. The heart normally produces low levels of a precursor protein, pro-BNP, which is cleaved to release the active hormone BNP and an inactive fragment, NT-proBNP. The purpose of BNP is to help regulate blood volume and, therefore, the work that the heart must do in pumping blood throughout the body. Both BNP and NT-proBNP are produced mainly in the heart’s left ventricle (the organ’s main pumping chamber). When the left ventricle is stretched from having to work harder, the concentrations of BNP and NT-proBNP in blood can increase markedly. This situation may occur in heart failure as well as other diseases that affect the heart and circulatory system.
How is the sample collected for testing?
A blood sample is obtained by inserting a needle into a vein in the arm.
NOTE: If undergoing medical tests makes you or someone you care for anxious, embarrassed, or even difficult to manage, you might consider reading one or more of the following articles: Coping with Test Pain, Discomfort, and Anxiety, Tips on Blood Testing, Tips to Help Children through Their Medical Tests, and Tips to Help the Elderly through Their Medical Tests.
Another article, Follow That Sample, provides a glimpse at the collection and processing of a blood sample and throat culture.
Is any test preparation needed to ensure the quality of the sample?
No test preparation is needed.
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This article was last reviewed on
September 26, 2008
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