Hypercoagulable Disorders
Overview | Activation Problems | Regulation Problems | Breakdown Problems | Other Factors | Laboratory Tests | Treatment | Related Pages
Problems with coagulation cascade regulation
Inherited:
- Activated Protein C resistance (Factor V Leiden mutation) -- a mutation in the gene that makes the factor V protein. Factor V is activated normally, but it is resistant to degradation by activated Protein C, which regulates the clotting process.
- Antithrombin (III) deficiency or dysfunction -- this is a factor that helps decrease the activity of the clotting process by inhibiting factors Xa, IXa, XIa, and thrombin. Inherited or acquired deficiency of antithrombin can lead to a clot formation.
- Protein C deficiency or dysfunction -- Protein C helps regulate the speed of the coagulation cascade by degrading activated factors V and VIII.
- Protein S deficiency or dysfunction -- Protein S is a cofactor with Protein C
- Prothrombin 20210 mutation -- a mutation that results in an increased amount of thrombin (activated factor II) in the circulation, which is associated with an increased risk for venous blood clots.
- Elevated factor VIII levels -- persistently elevated factor VIII levels that are not associated with inflammation or other acquired conditions but are associated with an increased thrombotic risk.
Acquired:
- Antiphospholipid syndrome (lupus anticoagulant and anticardiolipin antibody)
- Disseminated intravascular coagulation (DIC)
- Bone marrow disorders such as myeloproliferative disorders
- In very rare cases, antibodies to coagulation factors; most factor antibodies cause bleeding episodes, not clotting problems.
- Systemic lupus erythematosus - an autoimmune disorder
